Shellshock live aim assist5/2/2023 ![]() ![]() Now DON'T move, count 3 ticks left, switch to Horizon and fire to kill the left-most AI.įor the last AI (still keep yourself in place), aim 45º right, max force, count 15 ticks left and 45 ticks down, then fire the strongest thing you've got there. (image is wrong because of tank upgrade issues) Move again all the way right, aim straight up, count 20 ticks right and fire another normal Shot to hit the smaller target. Move all the way right, aim 45º right, max force, count 2 ticks right and fire a normal Shot to hit the bigger target. Besides being a very obvious reference, they're very helpful, especially when you're in a hole and they spawn right above you (considering it's your turn and nobody else's). Thinking With PortalsShots: Limited (6 - 1 Breaker, 1 Horizon, 3 Shot, 1 Splitter) Upgrading tracks can (and will) make missions like Thinking with Portals NOT work (bot battles are fine though, you can do as you wish but think twice and be sure to reset before trying missions like these). Oh, and a word of advice: this guide was made with the following in mind: RESET YOUR UPGRADES TO DO THE MISSIONS. Ok, you're all prepped up, let's do some missions. Keep that in mind, as it can change the outcome of your mission (shots may miss if you're not in an exact position). If you see the expression "move all the way right", for example, it means "go right until your fuel goes to 0". I may also aid you whether you'll have to move or not, along with how much fuel you have in the mission (or whether there's not fuel at all), and if you have pre-set weapons or not. Sure, you can aim with the mouse too, it's your playstyle after all, but keep in mind using the arrows is way more accurate and they may help you when you want to snipe that little tank fella. ![]() Here's a screenshot to make it easier for you to get the hang of aiming, along with the most common degrees. aim straight left = 0º left, max force (100) aim straight up = 90º up, max force (100) You have a 360º angle, plus a force from 0 to 100, so that means: So if you aim straight up (90º) and you go, let's say, 10 ticks right, you have pressed the right arrow key 10 times and are now aiming at a 80º angle. Ticks are often used to make shots more accurate, since you have a 360º angle to fire. If you used the keyboard arrows to play you may have noticed each time you press one of the keys, you hear a "tick" sound. If not, go play the Tutorial right now and come back later. ![]() If you played the Tutorial I hope you're already used to the game's basic commands. If you know this already, feel free to skip this. This will help the developers to catch the hackers and make ShellShock.io a fairer and more enjoyable game for everyone.Before starting this, I'll teach some expressions most veteran players use, like "ticks". As gamers, we should also do our part and report anyone who we suspect of hacking. They’re also keeping an eye out for anyone who is hacking and are taking action to ban them from the game. The developers of the game are working tirelessly to fix the hack and improve security measures. The Solution to ShellShock.io Hackįortunately, there is a solution to ShellShock.io hack. It can provide the hacker with an unfair advantage and ruin the gameplay experience for other gamers. This is basically a code that they use to cheat in the game. Another way hackers use ShellShock.io hack is by using the script. Using the aimbot makes it much easier for the hacker to win the game, as they’re not playing the game fairly. This allows the player to easily shoot other players, even if they’re not in view. One of the main ways hackers use ShellShock.io hack is by using the aimbot. Aimbot and Script- How They’re Used in ShellShock.io Hack ![]() The developer of the game has put in a lot of time and work to create a fun game for players to enjoy, and hacking the game just ruins the experience for others. It’s also unfair and shows that the hacker is not playing the game fairly. Players who use the hack are cheating, and this can cause other players to be upset and leave the game. The effects of ShellShock.io hack are detrimental to the in-game experience. ShellShock.io hack is a big problem, as it’s allowing players to cheat by using an aimbot, wallhack or script. As the game gained popularity, so did ShellShock.io hack 2022, which has become a serious issue that the developers of the game are trying to deal with. ShellShock.io is a popular multiplayer game that’s being played by many gamers around the world. ShellShock.io Hack: A Serious Problem in 2022 What is ShellShock.io? ![]()
0 Comments
Kinecta iclock radio5/2/2023 ![]() Some models even run away from you, so you’re forced to get out of bed to shut them off! Clock radio pricesĪt this price, clock radios will have functions such as a radio tuner, a number of presets so you can program your favorite radio stations, and a snooze button. Other units double as charging docks for smartphones. Some high-tech clock radios incorporate additional features like room temperature readings and weather updates for the day ahead. There is no fail-safe if the battery runs out in the middle of the night. If the power goes out, you won’t miss that important meeting in the morning. Most clock radios require an outlet for power, but some have batteries for backup power. Out of everything in your life, your clock radio should be the least of your worries. Buttons should be responsive, easy to press, and intuitive. Programming your favorite radio stations should also be easy. Make sure setting the alarm is simple enough that you don’t run into problems that leave you racing to work. You won’t get any use out of a feature-heavy unit if it’s too hard to program. ![]() When deciding on a clock radio, consider its ease of use. If you sleep like a rock and constantly ignore your alarm, a more persistent clock radio may be right for you. If you have difficulty sleeping, you might need a clock radio with features that help you drift off peacefully. If you work odd shifts or have to get up early in the winter when it’s still dark out, a sunrise simulator may help with morning grogginess. If you’re a very heavy sleeper, sound quality – and volume – may be more important to you than other features. ![]() If you’re thinking about buying a new clock radio for your boudoir, first think about your sleep habits. ![]() If you want to save space on your bedside table, opt for a clock radio that doubles as a light. ![]() Toribash cheats5/2/2023 ![]() ![]() This will be especially useful if you need to draw a lot of textures which will normally get capped by max texture limit.Īll Lua hooks are now executed in a predetermined order You can now load a single master texture and render its specific parts. With 5.60 we're adding documentation for all existing Toribash functions as well as for built-in classes like UIElement or PlayerInfo.ĮmmyLua is available as an extension for VSCode or IntelliJ IDEA.Ĭurrent alpha version does not have the final documentation yet and will receive further updates closer to stable release. We know Toribash has been notorious for its lack of documentation when it comes to game-specific Lua functionality. What's new in Toribash 5.60: Lua replay manipulation updatesĪll player or environment changes (position, rotation, velocity, etc) triggered with Lua are now properly stored in replay files. HEAD IN GAME AND PLAY THE PROTECTOR CHAPTER V: MURDER MYSTERY!! The Chief of Police was murdered tonight and left with a harrowing message, "He's Coming" Why did they kill him? Who's next? What's coming? Let's get to the bottom of this. The 9 Blades doesn't end with Kira, their murderous rampage continuous. We're investigating a string of murders connected with the 9 Blades gang. ![]() I've been stranded down here in your lands but my work is far from finished. I am The Protector and I come from the distant dystopian sky city of New Cybron. Welcome to Chapter 5 of the Protector Saga There is a darkness coming, and only we can stop it. ![]() Allen datagraph 536 for sale5/2/2023 ![]() ![]() Complete design (layout) and output (plot) software. Design Mart will assist in developing print brochures. Modified Roman, Condensed Modified Roman, Vermarco, Goverment, Hebrew, Old English, Script, Russian, Uncial Gothic, plus hundreds more! For hard surface materials: Granite, Marble, Glass, Mirrors, Acrylics, Brass, and more. Portable and can be positioned directly over the stone. Now available with a three year warranty. Utilizing automatic gap-tracking technology, the Granite Impact Etcher Series eliminates focusing or a need It can achieve good visibility even on stones that have poorer contast. The diamond needle physically kits the stone, creating images that are close to manual etching. Is a non-laser, easy-to-use, reliable machine. Have all the equipment available for one visit to the cemetery saving time and money, rather than traveling back and forth to the shop. Unit includes rugged carrying case and a power inverter to power the cutter and your laptop. The GS15plus with Hyatt's custom case - makes it portable for on-site final death dates and graphics. Do the entire job on-site saving time and money, rather than traveling back and forth to the shop. The Allen 315GS with options for portable use. Signlab and more! Two-year manufacturer's warranty included. Faultless, unattended operation with on-the-fly adjustable speed and force settings. Table-top, high-speed, rugged enough for stencil cutting of monument designs. Includes a one-year warranty, accessory kit, blade holder, blade, pen and roll holder. The GS15plus is the most accurate 15" plotter on the market when using a tangential knife while cutting sandblast materials. The GS15plus sprocket plotter uses 15" perforated media to cut text or graphics up to 13.25 inches in height. An additional benefit is that the 526 GTS cuts to the edge of the holes on both sides of the material allowing a 2-0X2-0 die to cut perfectly between the hole punch pattern. The flexibility of the 536 GTS permits cutting 10, 12, 15, 18, 21, 25 and 30-inch stencil. The 536 GTS is a dual drive cutter that can utilize either sprocket drive for heavy sandblast materials, or a friction drive for more accurate cuts on thinner material. THe GS750 can use either a swivel or tangential-knife blade! Made in USA. Uses 30" perforated materials and can cut text and graphics up to 27.25" in height. Gerber OMEGA software will drive any cutter on this page! See "software" section.Īn industry favorite for over 20-years, the GS750M withstands the rigors of daily stencil cutting. Online training with GoToMeeting included free, or optional on-site installation and training available at additional charge. Includes free roll of Anchor Continental 25" stencil. Any IP address will work as long as its uniqueon your network and can be found using the ping command prompt command from yourcomputer.Start the Enable Printer Driver program:Start -> All Programs -> Allen Datagraph -> Cutter Driver -> Enable Printer DriverAnswer No to this questionTechnical Support BulletinInstall the DirectCutPrinter Driver to Fixed IPLast update 6-7-12Selectbutton from the driver installation.Features the Allen Datagraph 536 GTS cutter, with Omega CS software and Design Mart designer package of choice. Replace any reference to 192.168.4.2 in theinstructions with the IP address you chose. For this document assume the IT department chose192.168.4.2 for your static IP address. Ask your IT department to assign a static IPaddress for your network. Driver InstallAbstract: On some computers and networks the spooler cannot find the IP address of thecutter automatically and displays waiting for LAN port to exist in the spooler window.This procedure describes a manual installation of the cutter driver to a fixed instead of adynamic IP address.Its best to do this procedure with the cutter off and only if the auto procedure fails.Use diagnostic 4 on the cutter to assign a static IP address as described in the usersmanual of the cutter you are installing. ![]() Separation studio software5/2/2023 ![]() Sep Studio NXT auto detects a file format then properly separates a file into either Sim Process or raster spot color separations. Set your creativity free with Spot Process™ Separation Studio™ 4 and get creative even during output with a full load of pre-print features that deliver precise control while producing top-notch films. Sep Studio NXT driven by our legendary Spot Process color separation engine will make easy work of your most challenging separation needs. No external RIP needed to print Sep Studio™ 4 separations ![]() PressFit™ gives you drag and drop control to reduce press screens in a production run Working with libraries is the most efficient way to work SoundHound SoundHound is essentially a song identification app. Textile and press ink custom libraries connect what you see on-screen to what will happen on-press. At its core is an AI software armed with interactive audio visuals featuring video walls, digital signage, whiteboards, projection displays, presentation systems, and other features that make for seamless remote meetings. The amount of time this auto feature saves each screen print artist is immeasurable Underbase with choke and spread is the screen print specific ability you’ve been searching forĪuto convert process to spot colors and reduce screens in customer supplied files and downloaded stock art. Transparency support (PSD) means placing graphics in front and behind tonal images is always easy when using Adobe and Corel programs Video Tutorial is available on our support page.Vector PDF support in its own powerful engine Review Spot Process Separation Studio 4 Screen Printing Separation Software. GitLab is a single application for the entire software development lifecycle. Star After separation, you can save your C, M, Y and K colors or Single Color Separation into separate files with desired shape and shape size.Ĭolor Separation is used in T-Shirt Screen Printing and many other Printing areas. As the name PEI sheets can be damaged if no separation layer is used. CMYK Color Separation - image is separated into Cyan, Magenta, Yellow and Black colors.Single Color Separation - separates whole image.Just open your graphic artwork with Separation Studio and let it make easy work of it! Works with JPG, PNG, BMP, TIFF, GIF, PDF, SVG, PCT, XBM, HEIC and JPEG-2000 file types. Best of all, this ImagePrint Tutorial teaches. Just Open your image file with Separation Studio, and it will do the rest. proudly offers ImagePrint RIP Software for screen printing. ![]() ![]() ![]() You don't need any other software to separate your graphics colors. The separations can be based on shapes defined in the application. Separation Studio is an application that allows you to create single color and CMYK half-tone patterns in vector-based formats. Separation Studio is powerful, easy to use color separation and artwork generator tool designed exclusively for Mac. Separation Studio helps you to: Auto convert to spot colors and reduce screens Edit and erase unwanted data from image files Generate white under base for. ![]() Intellij idea 15 license5/1/2023 ![]() ![]() However, it comes with the latest codes to build the app designs. All in all, this accompanies the useful and reliable tools used for a lifetime after activation. Besides, the app repairs and fixes the app’s codes and more. Moreover, it facilitates to execution of the desktop app in a smoother, easier, and faster way. ![]() Henceforth, you can run this latest product for Java language, technology, and even for Science. Similarly, it gives the power to create all kinds of apps or programs without wasting time. In other words, jetbrains java Keygen is the latest product to build web, mobile, and desktop apps in a short time. Even, the program gives the scrolling suggested words, jetbrains intellij, keywords, and more. Also, it is suitable for professional customization and professional users. Henceforth, the clients can develop the entire program without any code error leaving the outcome the most efficient. In such a manner, you can remove them at the time they occur to make the results error-free and efficient. Besides, with this program, you can save your time as it shows all the errors taking place in the app. All in all, the clients may get it to create a clean environment to complete the tasks. Further, this lets you use it in your native language as it supports various languages. IntelliJ python Torrent Moreover, it works as the whole editing app giving simple methods to design and create software. However, the app goes about as an efficient and powerful IDE with lots of useful tools. Intellij IDEA as Productive IDE with Superb Tools: Therefore, they may get the wanted apps in a desired and quick manner. Additionally, the app entrusts the clients to create more productive app ideas with the aid of this app. On the other hand, it permits the users to show their abilities with amazing built-in tools of the product. In this way, you may use the static ways to design the required apps and can also analyze the codes. Intellij IDEA Product Key creates mobile apps like the Android apps in no time. However, it has a full package of tools to develop programs for mobile platforms and web enterprises. Similarly, serial keys are required to access the benefits of the entire features of the product. In addition, the app has many more tools than you think which gives superb outcomes beyond expectations. All in all, in a way to develop the program codes, it participates very actively. Moreover, this product accompanies the vital factors in it to work proficiently. Significant Factors Added in IntelliJ IDEA Activation Key: On the other hand, this stops the irrelevant suggestions and provides only suitable forms related to recent context. Thus, Intellij IDEA Registration Key suggests the names, keywords, fields, methods, and the class scope as well. Essentially, it is developed in a way to create many amazing projects since it offers great ideas as well. ![]() Moreover, the product can create instant codes, analysis, and more tasks. Similarly, it incorporates the new features in the latest upgraded version. Additionally, you can utilize the program in a manner to effectively design the apps without hassle or plugin. Further, the app has mission-critical options with a variety of system and language support. IntelliJ IDEA Activation Key Besides, this will increase your creation rate and gives superb results. In other words, it is an advanced static analyzer for code analysis and design analysis. You can also Download: Loaris Trojan Remover How to Utilize Intellij IDEA Keygen?Īll in all, the app is utilized to create a super Java integrated atmosphere. Although Intellij IDEA Activation Code is an IDE for Java, it understands and provides intelligent encoding aids for a variety of other languages such as SQL, JPQL, HTML, JavaScript, etc., even if the language expression is included in a string of characters in your Java code. While the basic completion suggests class names, methods, fields, and keywords in the scope of visibility, intelligent completion only suggests the types expected in the current context. Intellij IDEA Serial Number has all the critical tools, such as built-in version control systems and a variety of supported languages and structures, which are all available without plug-in problems. After indexing your source code, Intellij IDEA License Key offers a fast and intelligent experience by making relevant suggestions in all contexts: immediate and intelligent code completion, direct code analysis, and reliable refactoring tools. Together, powerful static code analysis and ergonomic design make development not only productive but also enjoyable. The Intellij IDEA Keygen that has been specifically designed to maximize developer productivity. Intellij IDEA Crack v2022.3.2 With Activation Code Full Download Latest Version 2023 ![]() ![]() ![]() It enables you to change the format type of a certain image file to anything you wish including JPEG, GIF, PNG, PDF, BMP, TIFF and so much more. Once you install the program you will have a good handle on it within a few minutes of use. Pixillion Image Converter is a completely free and comprehensive multi-format photography suite. reduce file size for sending via email or storing on a CD as well as quickly convert to the image format needed for other software applications.It shows a real-time preview before conversion, as well as. It is full offline installer standalone setup of Pixillion Image Converter Plus 2021. This, in my opinion, is more of a positive than a negative. Pixillion Image Converter Plus 2021 Free Download. Do you have trouble completely uninstalling. There are very few bells and whistles to the program so don't expect a complicated piece of software. Pixillion is one of the most stable, easy-to-use, and comprehensive multi-format image file converters available. Using Pixillion Image Converter is pretty much dummy proof. So far I have been able to convert photos from my iphone, and files from PDF to JPEG for online use without problem. Converter download - AVCWare DVD to DPG Converter 6. If you're an expert maybe 30 minutes which brings me to my next point. This program, though not in the end free, (that is only the trial version) has been a great help to me in converting image files to be used in my online classes. Concerting images the old fashion was can take you the better half of an hour if you have no idea what you are doing. If you've ever done image conversion before you know exactly how much of a lifesaver this is. Before converting your file Pixillion allows you to view the image within the application as well as displaying the current file parameters. Quickly convert any image between a number of different formats with one click.Īnother great thing about Pixillion Image Converter is that I can set up a full album of images and convert them with a single click. Pixillion Image Converter Software Free can convert files from and to JPEG and other file formats like gif, tiff, png, pdf and more. In addition to that, I am able to edit the images with captions and even placing watermarks which is a great anti-theft tool. I personally use Pixillion Image Converter to resize my images and convert them so they fit my site properly. ![]() You have to make sure the image is in the right format, fits the screen right, and the list goes on. Preview picture results before any conversionĪs a blogger, images are one of the biggest hassles to deal with next to creating content.Convert images between gif,pdf,png,and jpeg.Pixillion Image Converter fixes all of that. Shop for Pixillion Image Converter Software for Mac- Convert Photo and Image File Formats Download online at an affordable. As a blogger myself, I can speak from experience when I say images are a pain to manage. While Pixillion Image Converter is great for those who work in photography, it is also great for people who work with websites as well. The impressive program allows its users to seamlessly convert images between several different formats. Pixillion Image Converter Software Free can convert files from and to JPEG. There are very few bells and whistles to the program so dont expect a complicated piece of software. Image Converter One includes the four most basic tools to work with your photos, though they're not as complete as standalone alternatives.Pixillion Image Converter is a top of the line software that is designed for men and women who work with images. Pixillion is a free JPEG and image file format conversion software for Windows. Using Pixillion Image Converter is pretty much dummy proof. As for the watermarking tool, I'd have preferred to see the watermark as it'll appear on my actual photo, not a sample image. The resizing tool, for example, lacks predefined profiles, which means you always have to enter the new size values by hand. I found Image Converter One to be quite a handy program, mainly due to the fact that it includes several apps in one. If you have a rare image format that you cant open, this program can probably convert it. it works so good for me and I hope to enjoy this software more than. Microsoft Save as PDF or XPS (Ocircan Micheal) I love it. (James Kang) Its very good for real-time measurement, the use of this software is very professional. You can also decide whether you want to overwrite the original files or saved the images you just processed with a different name. It can convert any of around 500 image formats to your choice of around 80 others. SPACE GASS (Roland ZOA) Good software for reinforced concrete design. Simply select the images you want to work with and then choose the appropriate action. All in all, Pixillion Image Converter is a great file converter software you can use if you want simple and straightforward image conversions in a few seconds. ![]() Its time for change5/1/2023 ![]() ![]() The issue is that for every argument there is a counterargument. Studies over the last 25 years have shown the one-hour change disrupts body rhythms tuned to Earth's rotation, adding fuel to the debate over whether having Daylight Saving Time in any form is a good idea. The bill would need to pass the House of Representatives and be signed by President Joe Biden to become law. The twice-yearly switcheroo is irritating enough to lawmakers of all political stripes that the US Senate passed legislation in March 2022 to make Daylight Saving Time permanent. In the US, states are not required by law to "fall back" or "spring forward." Hawaii and most of Arizona do not observe Daylight Saving Time. Schools across the country delayed start times until the sun came up.īy summer, public approval had plummeted, and in early October Congress voted to switch back to standard time. But by the end of the month, Florida's governor had called for the law's repeal after eight schoolchildren were hit by cars in the dark. It was a popular move at the time when President Richard Nixon signed the law in January 1974. Only 17% wanted to keep what was then called "war time" all year.ĭuring the energy crisis of the 1970s, we tried permanent Daylight Saving Time again in the winter of 1973-1974. As the war came to a close in 1945, Gallup asked respondents how we should tell time. The idea was put in place to conserve fuel and keep things standard. The US kept Daylight Saving Time permanent during most of World War II. Pro tip: It's Daylight Saving Time, with singular use of "saving," not "savings." Daylight Saving Time has its roots in train schedules, but it was put into practice in Europe and the United States to save fuel and power during World War I, according to the US Department of Transportation's Bureau of Transportation Statistics. The current March to November system that the US follows began in 2007, but the concept of "saving daylight" is much older. On the first Sunday of November, at 2 a.m., clocks fall back an hour to standard time. On the second Sunday of March, at 2 a.m., clocks in most of the United States and many other countries move forward one hour and stay there for nearly eight months in what is called Daylight Saving Time. ![]() MIAMI - It's almost time for clocks to "spring forward" one hour. ![]() Playr kirby5/1/2023 ![]() ![]() Montreal Canadiens | Kirby Dach | Dach had a power-play assist, five shots on goal, one hit and two penalty minutes over 18:51 of ice time in Saturday's 5-3 loss to Edmonton. Montreal Canadiens | Kirby Dach | Dach registered an assist and went plus-2 in Tuesday's 4-2 win over the Seattle Kraken. Montreal Canadiens | Kirby Dach | Dach started at center on the second line and had two hits over 18:25 of ice time in Saturday's 4-2 loss to the Los Angeles Kings. He added three shots on net and four penalty minutes over 22:27 of ice time. Montreal Canadiens | Kirby Dach | Dach scored the game-winning goal in Monday's 2-1 shootout victory over the Calgary Flames. He added one hit, one blocked shot and six penalty minutes over 18:01 of ice time. Montreal Canadiens | Kirby Dach | Dach scored a goal on two shots in Wednesday's 3-2 loss to Ottawa. Montreal Canadiens | Kirby Dach | Dach had a power-play assist, one shot on goal and two hits over 19:23 of ice time in Thursday's 5-2 loss to the Anaheim Ducks. Montreal Canadiens | Kirby Dach | Dach notched an assist in Monday's 3-2 overtime win over the Arizona Coyotes. Montreal Canadiens | Kirby Dach | Dach had a power-play assist, four shots on goal and two hits over 17:26 of ice time in Saturday's 9-2 loss to the Washington Capitals. Montreal Canadiens | Kirby Dach | Dach scored a power-play goal and had two hits over 19:38 of ice time in Saturday's 5-4 win over the St. Montreal Canadiens | Kirby Dach | Dach scored an even-strength goal and added a power-play assist in Thursday's 4-3 win over the Nashville Predators. Montreal Canadiens | Kirby Dach | Dach scored a goal on four shots in Sunday's 2-1 win over the New York Rangers. Montreal Canadiens | Kirby Dach | Dach picked up two assists in Tuesday's 4-1 win over the Winnipeg Jets. Montreal Canadiens | Kirby Dach | Dach tallied a pair of goals in Tuesday's 4-2 loss to the Boston Bruins. Montreal Canadiens | Kirby Dach | Dach had a short-handed assist, one shot on goal, three blocked shots and five penalty minutes over 22:01 of ice time in Thursday's 4-3 overtime loss to Detroit. ![]() Montreal Canadiens | Kirby Dach | Dach scored a power-play goal in Montreal's 5-4 loss to Ottawa on Tuesday. ![]() He added three hits and one blocked shot over 19:29 of ice time. Montreal Canadiens | Kirby Dach | Dach scored a goal on his lone shot in Saturday's 4-3 overtime win over the New York Islanders. Montreal Canadiens | Kirby Dach | Dach logged a short-handed assist and one shot on goal over 17:37 of ice time in Sunday's 6-2 win over the Edmonton Oilers. Montreal Canadiens | Kirby Dach | Dach will miss Thursday's game against the Carolina Hurricanes because of a non-COVID illness. Montreal Canadiens | Kirby Dach | Dach (illness) skated briefly Saturday morning but won't play Saturday per Renaud Lavoie of TVA Sports. Montreal Canadiens | Kirby Dach | Dach (illness) will not travel with the team for Tuesday's road clash with the New Jersey Devils, Arpon Basu of The Athletic reports. Montreal Canadiens | Kirby Dach | Dach (lower body) will not play in Philadelphia on Friday. Montreal Canadiens | Kirby Dach | Dach (lower body) won't play Saturday versus the Ottawa Senators, Arpon Basu of The Athletic reports. Montreal Canadiens | Kirby Dach | Dach (lower body) won't travel with the Montreal Canadiens and is considered out indefinitely. Montreal Canadiens | Kirby Dach | Dach (lower body) remains out indefinitely. ![]() Hexavalent chromium exposure5/1/2023 ![]() ![]() The Zn was detected as 56.75 ± 7.86 mg/kg and 1.83 ± 0.76 mg/kg in the muscle and fat of females and 52.12 ± 11.51 mg/kg and 1.94 ± 0.57 mg/kg in males, respectively. Manganese concentration of muscle was 0.45 ± 0.30 mg/kg (female) and 1.36 ± 0.96 mg/kg (male), and that of fat tissue was 0.32 ± 0.22 mg/kg (female) and 0.74 ± 0.75 mg/kg (male). The same tendency was observed in the case of copper content of fat tissues (female: 0.13 ± 0.10 mg/kg male: 0.13 ± 0.04 mg/kg p = 0.2707). The measured concentration of Cr was 0.14 ± 0.08 mg/kg and 0.13 ± 0.06 mg/kg, and that of copper was 1.22 ± 0.14 mg/kg and 1.06 ± 0.16 mg/kg in the muscle of females and males, respectively. ![]() The lead was detected as 0.36 ± 0.16 mg/kg and 0.22 ± 0.06 mg/kg in the muscle of females and males, respectively, showing a significant difference between the sexes (p = 0.0184). The concentrations of As, Hg, and Cd were below the limit of detection (As, Hg: < 0.5 mg/kg, Cd: < 0.05 mg/kg) in every tissue sample of both sexes. The concentrations of essential and non-essential elements were determined (arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), lead (Pb), manganese (Mn), mercury (Hg), and zinc (Zn)) using inductively coupled plasma optical emission spectrometry. The study was performed on 10 female and 10 male wild boars (Sus scrofa) after shooting during the regular hunting season to investigate the concentration of metals in the muscle and fat tissue. Since both of these two values were lower than the TDI, 1.1 μg/kg bw/day, FSCJ concluded the risk of health effects from Cr (VI) at the current exposure through the consumption of mineral water and tap water to be extremely low. 0.04 μg/kg bw/day and 0.290 μg/kg bw/day, respectively. The estimation gave the mean and high intakes as ca. Since chromium in food is regarded to be present as trivalent chromium³⁾, FSCJ estimated daily intake of Cr (VI) from consumption of mineral water and tap water. FSCJ specified the TDI of Cr (VI) as 1.1 μg/kg bw/day after applying the uncertainty factor of 100 to BMDL10 of 0.11 mg/kg bw/day, which was ascribed on the diffuse epithelial hyperplasia in the duodenum in male mice observed in the two-year oral exposure study. Consequently, specifying a tolerable daily intake (TDI), based on the results of animal studies with oral exposure to Cr (VI) through drinking water, is rather feasible. FSCJ considered that the quantitative risk assessment of Cr (VI) through drinking water was difficult to conduct based on the results from epidemiological studies of non-occupational and occupational exposures in human population. On the basis of these results, FSCJ judged that the carcinogenic mechanism of Cr (VI) intakes through drinking water was hardly attributable to the genotoxicity. In the in vivo gene mutation assays using transgenic rats and mice, no significant increases in mutant frequencies of the transgenes were observed in the carcinogenic target tissues, after exposure to Cr (VI) in drinking water for either 28 (rats) or 90 days (mice)1),²⁾. ![]() The mechanism of small intestinal tumors in mice is considered as follows: Continuous damage to mucosal epithelium in the small intestine by long-term exposure to Cr (VI) induces the hyperplasia in the crypt of small intestine, which would lead to the formation of tumor. These data indicate the genotoxic properties of Cr (VI), though genotoxicity by the oral administration including drinking water remains unclear. Cr (VI) showed positive results in many genotoxic studies in vitro, and in vivo after parenteral administration, whereas no clear positive results were obtained after the oral administration. Therefore, FSCJ considered that Cr (VI) is carcinogenic. Regarding to carcinogenicity, Cr (VI)-treatment by drinking water significantly increased incidences of tumors in the small intestine in mice and in the oral mucosa and tongue in rats. The finding observed at the lowest LOAEL was diffuse hyperplasia of mucosal epithelium in the duodenum in mice. Major toxicities induced by Cr (VI) were damages to small intestine and anemia in experimental animals. The Food Safety Commission of Japan (FSCJ) conducted a risk assessment of hexavalent chromium, hereinafter referred to as Cr (VI), related to the amendment of the standards for beverages established by the Ministry of Health, Labour and Welfare. ![]() AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |